Saline-enhanced radio-frequency tissue ablation in the treatment of liver metastases

Radiology. 1997 Jan;202(1):205-10. doi: 10.1148/radiology.202.1.8988212.


Purpose: To assess the effect of intraparenchymal saline injection on the results of radio-frequency (RF) tissue ablation.

Materials and methods: Ex vivo and in vivo animal RF ablation was performed with and without intraparenchymal saline injection. Initially, saline was injected as a bolus (1-20 mL) before RF application. For subsequent in vivo studies, saline was injected as a bolus before RF application or continuously (1 mL/min) during RF application. Finally, 14 patients with liver metastases and one patient with primary cholangiocarcinoma were treated with the continuous infusion technique. A single RF electrode (tip exposure, 1-3 cm) was used with various ablation parameters.

Results: With pretreatment bolus injection of saline, lesions measured 1.4 cm +/- 0.1, 1.6 cm +/- 0.2, and 1.2 cm +/- 0.1 in ex vivo liver, in vivo animal muscle, and in vivo animal liver, respectively. Without saline enhancement, lesion sizes were 1.0 +/- 0.2, 1.2 +/- 0.2, and 0.8 +/- 0.1 cm, respectively. With continuous saline injection in in vivo pig liver, lesion size was 1.8 - 4.1 cm in diameter. In human tumors, necrosis volume was variable, but complete necrosis was seen in 13 of 25 lesions (diameter, 1.2-3.9 cm). Partial necrosis greater than 50% was seen in 12 lesions (diameter, 1.5-4.5 cm).

Conclusion: Saline-enhanced RF ablation might permit percutaneous destruction of large liver lesions.

MeSH terms

  • Adult
  • Aged
  • Animals
  • Catheter Ablation*
  • Cattle
  • Female
  • Humans
  • In Vitro Techniques
  • Injections
  • Liver Neoplasms / diagnostic imaging
  • Liver Neoplasms / secondary*
  • Liver Neoplasms / surgery*
  • Male
  • Middle Aged
  • Radiography, Interventional
  • Sodium Chloride / administration & dosage*
  • Swine
  • Tomography, X-Ray Computed


  • Sodium Chloride