Circadian rhythm, sleep, and epilepsy

J Clin Neurophysiol. 1996 Jan;13(1):32-50. doi: 10.1097/00004691-199601000-00004.

Abstract

This review article: (1) describes the circadian distribution of ictal and interictal events; (2) differentiates transitional arousal, non-rapid eye movement and rapid eye movement sleep components and their substrates; (3) suggests the means by which the neural generators of these seizure-prone vs. seizure-resistant sleep and arousal states modulate the timing of different seizure manifestations; (4) considers clinical and mechanistic findings for the reciprocal effects of seizures and antiepileptic drugs upon the sleep-wake cycle; and (5) assesses clinical and basic mechanisms of sleep deprivation effects upon seizures.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Anticonvulsants / adverse effects
  • Anticonvulsants / therapeutic use
  • Arousal / drug effects
  • Arousal / physiology
  • Brain / drug effects
  • Brain / physiopathology
  • Brain Mapping
  • Circadian Rhythm / drug effects
  • Circadian Rhythm / physiology*
  • Electroencephalography / drug effects
  • Epilepsy / drug therapy
  • Epilepsy / physiopathology*
  • Evoked Potentials / drug effects
  • Evoked Potentials / physiology
  • Humans
  • Sleep Deprivation / physiology
  • Sleep Wake Disorders / drug therapy
  • Sleep Wake Disorders / physiopathology*
  • Sleep, REM / drug effects
  • Sleep, REM / physiology

Substances

  • Anticonvulsants