Anti-inflammatory activity of topical nimesulide gel in various experimental models

Inflamm Res. 1996 Dec;45(12):590-2. doi: 10.1007/BF02312040.

Abstract

Objective and design: The anti-inflammatory activity of topically applied nimesulide gel was compared in different experimental models with that of diclofenac and piroxicam gels.

Material: Wistar albino rats of either sex were used.

Treatment: In acute models, 50 mg of nimesulide or diclofenac were applied to right hind paws 1 h (carrageenan) or immediately before (formalin) irritant injection (sub-plantar). In adjuvant arthritis, 50 mg of nimesulide, diclofenac or piroxicam were applied daily to injected paws for 14 days.

Methods: Paw volume was measured by plethysmograph. Statistical significance was tested with Student's t-test.

Results: In the carrageenan paw odema, topical nimesulide gel exhibited similar anti-inflammatory activity to diclofenac gel, and was more effective than diclofenac gel in formalin-paw odema. In both acute (18 h) and chronic (14 d) phases of adjuvant arthritis, nimesulide gel was more effective than diclofenac or piroxicam gels.

Conclusion: Topical nimesulide gel possesses higher anti-inflammatory activity than that of diclofenac or piroxicam gels.

Publication types

  • Comparative Study

MeSH terms

  • Administration, Topical
  • Animals
  • Anti-Inflammatory Agents, Non-Steroidal / administration & dosage
  • Anti-Inflammatory Agents, Non-Steroidal / pharmacology*
  • Anti-Inflammatory Agents, Non-Steroidal / therapeutic use
  • Arthritis, Experimental / chemically induced
  • Arthritis, Experimental / drug therapy
  • Diclofenac / administration & dosage
  • Diclofenac / pharmacology*
  • Diclofenac / therapeutic use
  • Disease Models, Animal
  • Edema / chemically induced
  • Edema / drug therapy
  • Female
  • Gels
  • Male
  • Piroxicam / administration & dosage
  • Piroxicam / pharmacology*
  • Piroxicam / therapeutic use
  • Rats
  • Rats, Wistar
  • Sulfonamides / administration & dosage
  • Sulfonamides / pharmacology*
  • Sulfonamides / therapeutic use

Substances

  • Anti-Inflammatory Agents, Non-Steroidal
  • Gels
  • Sulfonamides
  • Piroxicam
  • Diclofenac
  • nimesulide