Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
, 61 (3), 287-91

The Afferent Discharges From Sensors for Interleukin 1 Beta in the Hepatoportal System in the Anesthetized Rat

Affiliations

The Afferent Discharges From Sensors for Interleukin 1 Beta in the Hepatoportal System in the Anesthetized Rat

A Niijima. J Auton Nerv Syst.

Abstract

The effect of intraportal administrations of interleukin 1 beta (IL-1 beta) on the afferent activity of the hepatic branch of the vagus nerve was observed in urethane anesthetized rats. An intraportal injection of IL-1 beta in doses of 10 pg and 100 pg per animal (300-400 g body wt.) resulted in dose-dependent increase in the afferent activity, which lasted about 70-100 min. Further, intraportal injection of IL-1 beta (100 pg) induced reflex activation of efferent activity of the splenic (sympathetic) nerve and vagal thymic nerve. This reflex activation was not observed in hepatic vagotomized rat and after an administration of the same dose of IL-1 beta into the systemic vein in normal rat. The results suggest the existence of sensors for IL-1 beta which send information on IL-1 beta in the portal venous blood to the central nervous system through the hepatic branch of the vagus nerve and play some role in reflex regulation of immune function.

Similar articles

See all similar articles

Cited by 47 PubMed Central articles

See all "Cited by" articles

MeSH terms

LinkOut - more resources

Feedback