Lung transplantation for alpha 1-antitrypsin deficiency emphysema

Chest. 1996 Dec;110(6 Suppl):284S-294S. doi: 10.1378/chest.110.6_supplement.284s.


Lung transplantation is an option for appropriately selected patients with end-stage emphysema caused by alpha 1-antitrypsin deficiency. The functional results have been excellent after single or bilateral lung transplantation, and the medium-term survival results have been good. However, the role of alpha 1-antitrypsin replacement therapy after lung transplantation remains uncertain, and further investigation is needed.

Publication types

  • Review

MeSH terms

  • Humans
  • Lung Diseases, Obstructive / surgery
  • Lung Transplantation* / mortality
  • Lung Transplantation* / statistics & numerical data
  • Pulmonary Emphysema / mortality
  • Pulmonary Emphysema / physiopathology
  • Pulmonary Emphysema / surgery*
  • Recombinant Proteins / therapeutic use
  • Registries
  • Respiratory Function Tests
  • Survival Rate
  • United States
  • alpha 1-Antitrypsin / biosynthesis
  • alpha 1-Antitrypsin / therapeutic use
  • alpha 1-Antitrypsin Deficiency*


  • Recombinant Proteins
  • alpha 1-Antitrypsin