Masters of deception: a review of herpesvirus immune evasion strategies

Immunol Cell Biol. 1996 Dec;74(6):513-22. doi: 10.1038/icb.1996.84.


Herpesviruses have acquired a variety of different mechanisms to avoid the damaging effects of host immunity. Frequently, these viruses subvert normal immune regulatory functions utilized by the host. The focus of this review is upon herpesvirus genes encoding known or potential immunomodulatory proteins. Areas covered include inhibition of complement and antibody function, herpesvirus-encoded homologues of cytokines and chemokine receptors, and potential disruption of cellular recognition of virally infected targets.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Herpesviridae / immunology*
  • Herpesviridae / pathogenicity*
  • Herpesviridae Infections / etiology
  • Herpesviridae Infections / immunology*
  • Herpesviridae Infections / virology*
  • Humans
  • Molecular Sequence Data