Controlling HIV pathogenesis: the role of the noncytotoxic anti-HIV response of CD8+ T cells

Immunol Today. 1996 May;17(5):217-24. doi: 10.1016/0167-5699(96)10011-6.


Noncytotoxic CD8+ T cells may play a critical role in preventing progression to disease following human immunodeficiency virus (HIV) infection. This antiviral response, mediated by a novel CD8+ T-cell antiviral factor (CAF), occurs soon after infection and is maintained in asymptomatic individuals. Here, Jay Levy and colleagues propose that this antiviral activity represents a natural cellular immune reaction that controls HIV production and protects the host from potential harmful effects of cytotoxic T lymphocytes.

Publication types

  • Review

MeSH terms

  • CD8-Positive T-Lymphocytes / immunology*
  • Cytotoxicity, Immunologic*
  • HIV / immunology*
  • HIV / pathogenicity*
  • HIV Infections / etiology*
  • HIV Infections / immunology
  • HIV Infections / microbiology*
  • Humans