Abstract
The proto-oncogene-encoded transcription factor c-Jun activates genes in response to a number of inducers that act through mitogen-activated protein kinase (MAPK) signal transduction pathways. The activation of c-Jun after phosphorylation by MAPK is accompanied by a reduction in c-Jun ubiquitination and consequent stabilization of the protein. These results illustrate the relevance of regulated protein degradation in the signal-dependent control of gene expression.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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3T3 Cells
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Animals
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Calcium-Calmodulin-Dependent Protein Kinases / metabolism*
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Cell Cycle Proteins / metabolism
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GTP-Binding Proteins / metabolism
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Gene Expression Regulation
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JNK Mitogen-Activated Protein Kinases
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Mice
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Mitogen-Activated Protein Kinases*
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Phosphorylation
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Proto-Oncogene Proteins c-jun / metabolism*
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Signal Transduction
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Transfection
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Ubiquitins / metabolism*
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cdc42 GTP-Binding Protein, Saccharomyces cerevisiae
Substances
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Cell Cycle Proteins
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Proto-Oncogene Proteins c-jun
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Ubiquitins
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Calcium-Calmodulin-Dependent Protein Kinases
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JNK Mitogen-Activated Protein Kinases
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Mitogen-Activated Protein Kinases
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GTP-Binding Proteins
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cdc42 GTP-Binding Protein, Saccharomyces cerevisiae