Angiotensin-II-receptors: new targets for antihypertensive therapy

Clin Cardiol. 1997 Jan;20(1):3-6. doi: 10.1002/clc.4960200103.


The renin-angiotensin system regulates blood pressure and sodium homeostasis through a series of coordinated substrate-enzyme interactions. These interactions result in the production of angiotensin II (AII), which exerts a number of diverse biologic effects mediated through AII cell-surface receptors. Dysregulation of this system is implicated in the pathogenesis of various forms of hypertension. Traditional therapy for hypertension has included angiotensin-converting enzyme inhibitors, which block the production of AII. However, a new class of drugs, AT1-receptor blockers, now offers a number of benefits by specifically blocking the effects of AII at its physiologically relevant receptor.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Angiotensin II / physiology*
  • Angiotensin Receptor Antagonists*
  • Antihypertensive Agents / therapeutic use
  • Blood Pressure / physiology
  • Humans
  • Hypertension / drug therapy*
  • Hypertension / physiopathology
  • Receptors, Angiotensin / physiology
  • Renin-Angiotensin System / physiology


  • Angiotensin Receptor Antagonists
  • Antihypertensive Agents
  • Receptors, Angiotensin
  • Angiotensin II