Abstract
Two signalling molecules-Indian hedgehog and parathyroid hormone-related peptide-have been found to function in a negative feedback loop that is crucial for the coordinated regulation of the rate and extent of endochondral bone growth.
MeSH terms
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Animals
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Bone Development*
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Cartilage / embryology
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Cartilage / metabolism
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Cell Differentiation*
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Cell Division
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Growth Plate / cytology
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Growth Plate / metabolism
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Hedgehog Proteins
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Parathyroid Hormone-Related Protein
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Proteins / genetics
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Proteins / metabolism*
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Receptors, Parathyroid Hormone / metabolism
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Trans-Activators*
Substances
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Hedgehog Proteins
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Parathyroid Hormone-Related Protein
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Proteins
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Receptors, Parathyroid Hormone
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Trans-Activators