Bone growth: coordinating chondrocyte differentiation

Curr Biol. 1996 Dec 1;6(12):1577-80. doi: 10.1016/s0960-9822(02)70776-8.

Abstract

Two signalling molecules-Indian hedgehog and parathyroid hormone-related peptide-have been found to function in a negative feedback loop that is crucial for the coordinated regulation of the rate and extent of endochondral bone growth.

Publication types

  • Review

MeSH terms

  • Animals
  • Bone Development*
  • Cartilage / embryology
  • Cartilage / metabolism
  • Cell Differentiation*
  • Cell Division
  • Growth Plate / cytology
  • Growth Plate / metabolism
  • Hedgehog Proteins
  • Parathyroid Hormone-Related Protein
  • Proteins / genetics
  • Proteins / metabolism*
  • Receptors, Parathyroid Hormone / metabolism
  • Trans-Activators*

Substances

  • Hedgehog Proteins
  • Parathyroid Hormone-Related Protein
  • Proteins
  • Receptors, Parathyroid Hormone
  • Trans-Activators