Gen(om)e duplications in the evolution of early vertebrates

Curr Opin Genet Dev. 1996 Dec;6(6):715-22. doi: 10.1016/s0959-437x(96)80026-8.


Phylogenetic analyses and sequence surveys of developmental regulator gene families indicate that two large-scale gene duplications, most likely genome duplications, occurred in ancestors of vertebrates. Relaxed constraints allowed duplicated and thus redundant genes to diverge in a two stage mechanism. Neutral changes dominated at first but then positively selected regulatory changes evolved the novel and increasingly complex vertebrate developmental program.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Evolution, Molecular*
  • Genes, Regulator*
  • Genome
  • Humans
  • Multigene Family*
  • Vertebrates / genetics*