Neutral theory of molecular evolution

Curr Opin Genet Dev. 1996 Dec;6(6):767-72. doi: 10.1016/s0959-437x(96)80034-7.


DNA sequence data are generally interpreted as favouring Kimura's neutral theory but not without dissent and often with a great deal of controversy with respect to molecular clocks, DNA polymorphism, adaptive evolution, and gene genealogy. Although the theory serves as a guiding principle, many issues concerning mutation, recombination, and selection remain unsettled. Of particular importance is the need for more knowledge about the function and structure of molecules.

Publication types

  • Review

MeSH terms

  • Adaptation, Biological
  • Animals
  • DNA
  • Evolution, Molecular*
  • Humans
  • Models, Theoretical*
  • Polymorphism, Genetic


  • DNA