The structural basis of negative cooperativity: receptors and enzymes

Curr Opin Struct Biol. 1996 Dec;6(6):757-61. doi: 10.1016/s0959-440x(96)80004-2.


Crystal structures of the negatively cooperative aspartate receptor caught at intermediate stages in the binding process help to elucidate structural factors involved in ligand binding. The frequency of occurrence of negatively cooperative proteins suggests that sequential changes in binding patterns will be extensive in positively cooperative as well as in negatively cooperative and no cooperativity proteins.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Allosteric Regulation / physiology
  • Crystallography, X-Ray
  • Models, Chemical
  • Models, Molecular
  • Protein Binding
  • Protein Conformation
  • Receptors, Amino Acid / chemistry*


  • Receptors, Amino Acid
  • aspartic acid receptor