Protein-biotin interactions

Curr Opin Struct Biol. 1996 Dec;6(6):798-803. doi: 10.1016/s0959-440x(96)80010-8.


The three-dimensional structures of several biotin-binding proteins are now known, giving insights into the molecular architecture of the binding sites for biotin. In combination with biochemical and computational approaches, these structural insights provide the basis for our present understanding of biotin-protein interactions which, in some cases, give rise to spectacular binding constants.

Publication types

  • Review

MeSH terms

  • Bacterial Proteins / chemistry
  • Binding Sites
  • Biotin / biosynthesis
  • Biotin / metabolism*
  • Enzymes / chemistry
  • Models, Molecular
  • Protein Binding*
  • Protein Conformation
  • Protein Structure, Secondary
  • Streptavidin


  • Bacterial Proteins
  • Enzymes
  • Biotin
  • Streptavidin