Postoperative drowsiness and emetic sequelae correlate to total amount of carbon dioxide used during laparoscopic cholecystectomy

Surg Endosc. 1997 Jan;11(1):42-4. doi: 10.1007/s004649900292.

Abstract

Background: After laparoscopy with carbon dioxide (CO2) insufflation early postoperative recovery is often complicated with drowsiness and postoperative nausea and vomiting (PONV).

Methods: 25 ASA I-II patients undergoing elective laparoscopic cholecystectomy under standardized anaesthesia were studied in a randomized, prospective study. The conventional CO2 pneumoperitoneum was compared with the mechanical abdominal wall lift (AWL) method with minimal CO2 insufflation with special reference to postoperative recovery.

Results: Postoperative drowsiness was of a significantly longer duration with the conventional method (p < 0.001) compared with the AWL technique. There was a positive correlation with the total amount of CO2 used and the duration of drowsiness (r = 0.75, p < 0.01). PONV was seen significantly more often in patients with CO2 insufflation of more than 121 (p < 0.05).

Conclusions: Avoiding excessive CO2 is beneficial for smoother and more uneventful recovery after laparoscopic cholecystectomy.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Carbon Dioxide / administration & dosage
  • Carbon Dioxide / therapeutic use*
  • Cholecystectomy, Laparoscopic / adverse effects*
  • Cholecystectomy, Laparoscopic / methods
  • Dose-Response Relationship, Drug
  • Humans
  • Pneumoperitoneum, Artificial / adverse effects*
  • Postoperative Complications / physiopathology*
  • Prospective Studies
  • Sleep Stages
  • Vomiting

Substances

  • Carbon Dioxide