Desensitization of bladder sensory fibers by intravesical capsaicin has long lasting clinical and urodynamic effects in patients with hyperactive or hypersensitive bladder dysfunction

J Urol. 1997 Feb;157(2):585-9.


Purpose: Capsaicin was used to treat symptomatic patients with hyperactive or hypersensitive bladders.

Materials and methods: Capsaicin solution (1 mM.) was instilled into the bladder of 16 patients with spinal hyperreflexia, bladder instability or hypersensibility.

Results: Frequency decreased in 14 patients and continence was achieved in 10 of 14 incontinent cases. Mean first desire to void and maximal cystometric capacity increased significantly. These effects lasted for 6 to 12 months and were renewed following repeat treatment.

Conclusions: Bladder afferent desensitization with capsaicin is promising in patients with motor or sensory bladder dysfunction, although initial pungency might limit its use.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Administration, Intravesical
  • Adult
  • Aged
  • Capsaicin / pharmacology*
  • Female
  • Humans
  • Male
  • Middle Aged
  • Time Factors
  • Urinary Bladder / drug effects*
  • Urinary Bladder / innervation*
  • Urinary Bladder, Neurogenic / drug therapy*
  • Urinary Bladder, Neurogenic / physiopathology
  • Urodynamics / drug effects


  • Capsaicin