Comparative evaluation of the short-term bactericidal potential of a steroid-antibiotic combination versus steroid in the treatment of chronic bacterial blepharitis and conjunctivitis

Eur J Ophthalmol. Oct-Dec 1996;6(4):361-7.

Abstract

The effects of four days' treatment with topical Maxitrol (neomycin sulphate 3500 IU/mL, polymyxin-B sulphate 6000 IU/mL with dexamethasone 0.1%) were compared with those of Maxidex (dexamethasone 0.1% alone) in a double-masked study in 111 patients with bacterial blepharitis or conjunctivitis, 95 of whom were evaluable for efficacy. The majority of patients (N = 80) had chronic blepharitis. Maxitrol treatment resulted in a significantly greater reduction (90%) in bacterial counts and bacterial eradication (50%) compared with Maxidex (34% and 17% respectively). Maxitrol treatment also produced a significantly greater reduction in conjunctival discharge than did Maxidex, while the treatments were equally effective in alleviating other ocular signs and symptoms. It was concluded that use of a fixed dose combination steroid-antibiotic product was more effective for bacterial control and therapeutic efficacy in the treatment of chronic blepharitis and conjunctivitis patients than treatment with steroid alone. However, in the long-term treatment of chronic blepharitis the well-known toxic problems of neomycin sulphate have to be taken into account.

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Administration, Topical
  • Adult
  • Aged
  • Aged, 80 and over
  • Anti-Bacterial Agents / administration & dosage
  • Anti-Bacterial Agents / adverse effects
  • Anti-Bacterial Agents / therapeutic use*
  • Anti-Inflammatory Agents / administration & dosage
  • Anti-Inflammatory Agents / adverse effects
  • Anti-Inflammatory Agents / therapeutic use*
  • Blepharitis / drug therapy*
  • Blepharitis / microbiology
  • Chronic Disease
  • Colony Count, Microbial
  • Conjunctiva / drug effects
  • Conjunctiva / microbiology
  • Conjunctivitis, Bacterial / drug therapy*
  • Conjunctivitis, Bacterial / etiology
  • Dexamethasone / administration & dosage
  • Dexamethasone / adverse effects
  • Dexamethasone / therapeutic use*
  • Double-Blind Method
  • Drug Combinations
  • Eye Infections, Bacterial / drug therapy
  • Eye Infections, Bacterial / etiology
  • Eyelids / drug effects
  • Eyelids / microbiology
  • Female
  • Fluprednisolone / administration & dosage
  • Fluprednisolone / adverse effects
  • Fluprednisolone / therapeutic use*
  • Glucocorticoids
  • Gram-Negative Bacteria / isolation & purification
  • Gram-Positive Bacteria / isolation & purification
  • Humans
  • Male
  • Middle Aged
  • Neomycin / administration & dosage
  • Neomycin / adverse effects
  • Neomycin / therapeutic use*
  • Ophthalmic Solutions
  • Polymyxin B / administration & dosage
  • Polymyxin B / adverse effects
  • Polymyxin B / therapeutic use*

Substances

  • Anti-Bacterial Agents
  • Anti-Inflammatory Agents
  • Drug Combinations
  • Glucocorticoids
  • Ophthalmic Solutions
  • Maxitrol
  • Dexamethasone
  • Fluprednisolone
  • Neomycin
  • Polymyxin B