Atopic disease in seven-year-old children. Incidence in relation to family history

Acta Paediatr Scand. 1977 Jul;66(4):465-71. doi: 10.1111/j.1651-2227.1977.tb07928.x.


The incidence of atopic disease and its relation to the family history was studied by questionnaire in 1325 children, 7 years of age. A higher incidence of bronchial asthma (2.7%) was found than in a previous Swedish study. The total incidence of atopic disease in the children was 15.1% with a higher level when there was a double parental history of such disease (42.6%) as compared with a single such history (19.8%). When both parents had an identical type of atopic disease, i.e. respiratory or skin, the incidence of atopic disease was higher (72.2%) than when non-identical types occurred in the parents (20.8%). The findings support theories of a polygenic transmission of atopic disease as well as a genetic influence on symptom specificity in such disease and may be of value in genetic counselling.

MeSH terms

  • Age Factors
  • Asthma / epidemiology
  • Asthma / genetics
  • Child
  • Dermatitis, Atopic / epidemiology
  • Dermatitis, Atopic / genetics
  • Female
  • Humans
  • Hypersensitivity, Immediate / epidemiology*
  • Hypersensitivity, Immediate / genetics
  • Male
  • Otitis Media / epidemiology
  • Otitis Media / genetics
  • Rhinitis, Allergic, Seasonal / epidemiology
  • Rhinitis, Allergic, Seasonal / genetics
  • Sweden
  • Urticaria / epidemiology
  • Urticaria / genetics