[Neonatal diabetes mellitus associated with an autoimmune disease]

Arch Pediatr. 1996 Aug;3(8):782-4. doi: 10.1016/0929-693x(96)82160-9.
[Article in French]


Background: Insulin-dependent diabetes mellitus can be associated to an auto-immune disease. A similar association may be seen in the neonate.

Case report: A one-day-old boy was admitted for ketoacidosis due to diabetes mellitus. Investigation showed that he also suffered from an auto-immune enteropathy with several types of autoantibodies, particularly anti-enterocytes antibodies. Immunotherapy was ineffective. Multi-organ lesions developed subsequently, particularly a pulmonary disease responsible for the death at the age of 2 years.

Conclusion: Physiopathology of this association remains unclear and the report of further cases should help improve our knowledge.

Publication types

  • Case Reports
  • English Abstract

MeSH terms

  • Autoimmune Diseases / complications*
  • Diabetes Mellitus, Type 1 / complications*
  • Humans
  • Infant, Newborn
  • Intestinal Diseases / immunology*
  • Male