[Wilms tumor and Bloom syndrome]

Arch Pediatr. 1996 Aug;3(8):802-5. doi: 10.1016/0929-693x(96)82165-8.
[Article in French]


Bloom syndrome is characterized by growth failure, skin anomalies with sun sensitivity, minor anatomic defects, excessive chromosomic fragility and usually severe immune deficiency. The chromosome fragility predisposes these children to the development of hematologic malignancies and solid tumors.

Case report: Morgan, a 4-year-old boy with Bloom syndrome, developed a Wilms tumor. Chemotherapy was poorly tolerated. Two years later, the child died from an uncontrolled progressive disease.

Conclusion: This is the fourth reported case of Wilms tumor occurring in a child with Bloom syndrome. This possibility requires repeated abdominal ultrasonography in such patients.

Publication types

  • Case Reports
  • English Abstract

MeSH terms

  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Bloom Syndrome / complications*
  • Child, Preschool
  • Humans
  • Male
  • Wilms Tumor / complications*
  • Wilms Tumor / drug therapy