[Control mechanisms of cell transition from the G1 phase to the S phase--the R point]

Cas Lek Cesk. 1996 Oct 9;135(19):634-5.
[Article in Czech]


The critical moment of regulation when transition of the cell from the G1 to the S phase takes which is decisive for its division is the so-called R-point (restriction point). The disorder of molecular mechanisms controlling the passage of the cell through this site is an associated manifestation of most tumourous processes. A considerable part of this mechanism is the RB protein, binding transcription factors needed for the activation of genes effective in the S phase. Its binding capacity depends on the extent of phosphorylation and on the activity of the appropriate kinases and their inhibitors.

Publication types

  • English Abstract

MeSH terms

  • Cyclin-Dependent Kinases / physiology
  • Cyclins / physiology
  • G1 Phase / physiology*
  • Gene Expression Regulation
  • Retinoblastoma Protein / physiology
  • S Phase / physiology*


  • Cyclins
  • Retinoblastoma Protein
  • Cyclin-Dependent Kinases