Inhibition of histamine release by nedocromil sodium reduces exercise-induced hypoxemia in master athletes

Med Sci Sports Exerc. 1997 Jan;29(1):10-6. doi: 10.1097/00005768-199701000-00003.


During exercise in highly-trained older master athletes (MA), the impairment of pulmonary gas exchanges has been shown to be associated with a concomitant increase in histamine release (2). To determine the role of the histamine released (% H) during exercise-induced hypoxemia, seven MA (age 63.2 yr +/- 1.9), all of whom were known to develop exercise-induced hypoxemia, performed two maximal incremental exercise tests at a one-month interval after administration of nedocromil sodium (which inhibits histamine and other mediator release) or placebo in random double-blind order. During exercise testing, blood samples for arterial blood gas analysis and histamine assay were drawn at rest, exercise and recovery. Nedocromil sodium induced an inhibition in % H (0.57 +/- 0.03 at maximal load (Pmax) with placebo vs 0.24 +/- 0.02 with nedocromil sodium) linked with an improvement of pulmonary gas exchange (PaO2: 71.1 +/- 1.4 at Pmax with placebo vs 83.4 +/- 3 with nedocromil sodium; D(Ai-a)O2: 37.5 +/- 1.4 at Pmax vs 19.1 +/- 3.1, respectively). These results confirm the link established between the increase in histamine and exercise-induced hypoxemia in master athletes.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Aging / physiology*
  • Double-Blind Method
  • Exercise / physiology*
  • Exercise Test
  • Histamine / blood
  • Histamine Antagonists / pharmacology*
  • Humans
  • Hypoxia / etiology*
  • Hypoxia / physiopathology
  • Hypoxia / prevention & control*
  • Male
  • Middle Aged
  • Nedocromil / pharmacology*
  • Pulmonary Gas Exchange


  • Histamine Antagonists
  • Nedocromil
  • Histamine