Contrast media-associated nephrotoxicity

Semin Nephrol. 1997 Jan;17(1):15-26.


Contrast media-associated nephrotoxicity (CM-AN) continues to be a common cause of hospital-acquired acute renal failure. This review of CM-AN discusses the pathogenesis, clinical features, incidence, risk factors with an emphasis on pre-existing renal insufficiency and diabetes mellitus, volume of contrast media, low osmolar versus high osmolar contrast media, and prophylaxis. Although the literature contains an abundance of information concerning CM-AN, areas of uncertainty remain in respect to clinical significance, risk with modem day radiological techniques and contrast media, optimal prophylactic regimens, and criteria for creatinine screening before contrast media administration.

Publication types

  • Review

MeSH terms

  • Acute Kidney Injury / chemically induced*
  • Acute Kidney Injury / epidemiology
  • Acute Kidney Injury / prevention & control
  • Animals
  • Contrast Media / administration & dosage
  • Contrast Media / adverse effects*
  • Humans
  • Incidence
  • Infusions, Intravenous
  • Kidney / drug effects*
  • Risk Factors


  • Contrast Media