Paraneoplastic syndromes associated with small cell lung cancer

Chest Surg Clin N Am. 1997 Feb;7(1):65-80.


The term paraneoplastic syndrome refers to the ability of some tumors to produce signs and symptoms at a distance from the site of the primary tumor or its metastases. Paraneoplastic syndromes may develop before the diagnosis of carcinoma is made. Paraneoplastic syndromes associated with small cell lung cancer (SCLC) include endocrinologic abnormalities secondary to peptide hormone production, and neurologic sequelae due to autoantibody production. This article reviews the common paraneoplastic syndromes that may occur in patients with SCLC.

Publication types

  • Review

MeSH terms

  • ACTH Syndrome, Ectopic / etiology
  • Atrial Natriuretic Factor / physiology
  • Carcinoma, Small Cell / complications*
  • Cerebellar Diseases / etiology
  • Encephalomyelitis / etiology
  • Humans
  • Inappropriate ADH Syndrome / etiology
  • Lambert-Eaton Myasthenic Syndrome / etiology
  • Lung Neoplasms / complications*
  • Paraneoplastic Syndromes / diagnosis
  • Paraneoplastic Syndromes / etiology*
  • Paraneoplastic Syndromes / therapy
  • Retinal Diseases / etiology


  • Atrial Natriuretic Factor