Control of angiogenesis by the pericyte: molecular mechanisms and significance

EXS. 1997;79:419-28. doi: 10.1007/978-3-0348-9006-9_18.

Abstract

The microvasculature consists of endothelial cells (EC) with albuminally located pericytes. A number of clinical and experimental observations suggest that pericytes contribute to the regulation of microvascular growth and function. EC and pericytes appear to have a variety of means whereby they may influence one another, including soluble growth factors, gap junctions and adhesion molecules, to name a few. Co-culture systems have provided a good deal of evidence to support the concept that these two cells interact and that these communications are central to vessel assembly, growth control and normal function.

Publication types

  • Review

MeSH terms

  • Animals
  • Capillaries / cytology*
  • Capillaries / physiology*
  • Coculture Techniques
  • Endothelium, Vascular / physiology*
  • Gap Junctions / physiology
  • Growth Inhibitors / physiology
  • Growth Substances / physiology
  • Homeostasis
  • Humans
  • Integrins / physiology
  • Microcirculation / physiology*
  • Models, Cardiovascular
  • Neovascularization, Physiologic*

Substances

  • Growth Inhibitors
  • Growth Substances
  • Integrins