The high mobility group I-C gene (HMGI-C): polymorphism and genetic localization

Hum Genet. 1997 Jan;99(1):103-5. doi: 10.1007/s004390050320.

Abstract

We have identified a highly informative dinucleotide repeat in the 5'-flanking region of the human high mobility group I-C (HMGI-C) gene. This polymorphism consists of 18-37 copies of a (CT) repeat with an observed heterozygosity of 82-83% in African Americans and Caucasians. Linkage analysis in CEPH pedigrees localized the HMGI-C gene to chromosome region 12q13-15 with no recombination observed between HMCI-C and markers D12S102 and D12S8.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • African Americans
  • African Continental Ancestry Group / genetics
  • Chromosome Mapping
  • Chromosomes, Human, Pair 12*
  • DNA Primers
  • European Continental Ancestry Group / genetics
  • Gene Frequency
  • Genetic Linkage
  • Genetic Markers
  • HMGA2 Protein
  • High Mobility Group Proteins / biosynthesis
  • High Mobility Group Proteins / genetics*
  • Humans
  • Microsatellite Repeats
  • Nuclear Proteins / genetics
  • Pedigree
  • Pennsylvania
  • Polymerase Chain Reaction
  • Polymorphism, Genetic*
  • Recombination, Genetic

Substances

  • DNA Primers
  • Genetic Markers
  • HMGA2 Protein
  • High Mobility Group Proteins
  • Nuclear Proteins