Functional expression of GABA rho 3 receptors in Xenopus oocytes

Neurosci Res. 1996 Dec;26(4):387-90. doi: 10.1016/s0168-0102(96)01114-5.


Homomeric rat GABA rho 3 receptors were expressed in Xenopus oocytes, and their pharmacological profile was investigated electrophysiologically. GABA activated the rho 3 receptors with an EC50 value of 7.5 microM and a Hill coefficient of 1.6. The GABA-induced current was not antagonized by bicuculline (100 microM), but was blocked by picrotoxin (IC50: 0.68 microM for 100 microM GABA). The current was almost insensitive to pentobarbital, diazepam and a neurosteroid, 3 alpha-OH-DHP. Many of the pharmacological properties of the rho 3 subunit were similar to those of the previously reported rat rho 1 and rho 2 subunits and GABAC receptors.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Dose-Response Relationship, Drug
  • Female
  • Oocytes / drug effects
  • Picrotoxin / pharmacology*
  • Receptors, GABA / drug effects*
  • Xenopus laevis
  • gamma-Aminobutyric Acid / pharmacology*


  • Receptors, GABA
  • Picrotoxin
  • gamma-Aminobutyric Acid