Gastric cytoprotection of the non-steroidal anti-inflammatory sesquiterpene, beta-caryophyllene

Planta Med. 1996 Oct;62(5):469-70. doi: 10.1055/s-2006-957942.

Abstract

The gastric cytoprotective effect of beta-caryophyllene, an anti-inflammatory sesquiterpene, was investigated in rats. The oral administration of beta-caryophyllene to rats significantly inhibited gastric mucosal injuries induced by necrotizing agents such as absolute ethanol and 0.6 N HCl, although it failed to prevent water immersion stress- and indomethacin-induced gastric lesions. In addition, this compound hardly affected the secretion of gastric acid and pepsin. Thus, beta-caryophyllene elicited anti-inflammatory effects without any indication of gastric mucosal damage typical of non-steroidal anti-inflammatory agents. Furthermore, this compound manifested cytoprotective effects, rendering the two-dimensional efficacious beta-caryophyllene to be a clinically safe and potentially useful agent.

Publication types

  • Letter

MeSH terms

  • Animals
  • Anti-Inflammatory Agents, Non-Steroidal / chemistry
  • Anti-Inflammatory Agents, Non-Steroidal / isolation & purification
  • Anti-Inflammatory Agents, Non-Steroidal / pharmacology*
  • Ethanol / toxicity
  • Gastric Mucosa / drug effects*
  • Gastric Mucosa / pathology
  • Indomethacin / toxicity
  • Male
  • Polycyclic Sesquiterpenes
  • Rats
  • Rats, Sprague-Dawley
  • Sesquiterpenes / chemistry
  • Sesquiterpenes / isolation & purification
  • Sesquiterpenes / pharmacology*
  • Stomach Ulcer / prevention & control*

Substances

  • Anti-Inflammatory Agents, Non-Steroidal
  • Polycyclic Sesquiterpenes
  • Sesquiterpenes
  • Ethanol
  • caryophyllene
  • Indomethacin