The contralateral corneal endothelium in the iridocorneal endothelial syndrome

Arch Ophthalmol. 1997 Jan;115(1):40-4. doi: 10.1001/archopht.1997.01100150042006.


Objective: To evaluate the corneal endothelial morphometric measures of the contralateral, clinically uninvolved eye of patients with the iridocorneal endothelial (ICE) syndrome.

Design: A retrospective review of the specular microscopic photographs of the contralateral corneal endothelium of all patients with ICE syndrome seen at Mayo Clinic, Rochester, Minn.

Setting: Ophthalmology department, Mayo Clinic.

Participants: Twenty-eight patients with unilateral ICE syndrome who had bilateral endothelial photographs (ICE group) and 28 normal, age-matched control subjects (control group).

Main outcome measures: Percentage of hexagonal cells, coefficient of variation of cell area, and endothelial cell density.

Methods: For each patient and control, 100 endothelial cells were digitized from projected endothelial photomicrographs of the central corneas in the uninvolved eyes.

Results: A statistically significant decrease was noted in the mean percentage of hexagonal cells (ICE, 62%; control, 69%; P = .002), and an increase was noted in the mean coefficient of variation of cell area (ICE, 0.28; control, 0.25; P = .02) in the patients with ICE syndrome compared with normal, age-matched controls. The mean endothelial cell density did not differ significantly between the 2 groups (ICE, 2588; control, 2759; P = .10).

Conclusion: Our data suggest that the clinically uninvolved, contralateral eyes in patients with ICE syndrome have subclinical endothelial abnormalities as evidenced by a relatively low percentage of hexagonal cells and a relatively high coefficient of variation of cell area.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Aged
  • Cell Count
  • Corneal Diseases / complications*
  • Corneal Diseases / pathology*
  • Endothelium, Corneal / pathology*
  • Female
  • Humans
  • Iris Diseases / complications*
  • Male
  • Middle Aged
  • Photography
  • Retrospective Studies
  • Syndrome