A vector projection method for predicting supersecondary motifs

J Protein Chem. 1996 Nov;15(8):721-9. doi: 10.1007/BF01887145.


For the 11 types of most frequently occurring supersecondary motifs, we used a new method--the vector projection method--to predict a protein's supersecondary structure. In a training set of peptides and a test set of peptides we obtained a satisfactory result, with a prediction accuracy of about 90%. The high prediction accuracy indicates that this method is reasonable for predicting the folding motifs of proteins. This work provides insight into the problem of predicting a protein's local structure accurately, and is of particular value in protein modeling, prediction, and molecule design.

MeSH terms

  • Amino Acids / chemistry
  • Databases, Factual
  • Models, Molecular
  • Peptides / chemistry*
  • Probability
  • Protein Conformation
  • Protein Folding
  • Protein Structure, Secondary*
  • Software


  • Amino Acids
  • Peptides