Abstract
Most strains of Streptococcus mutans possess a 190-kDa protein antigen (PAc) on their cell surfaces, while strain GS-5 produces extracellularly a 155-kDa PAc protein. The pac gene of strain GS-5 consists of 3,477 bp and codes for a protein of 1,158 amino acids. One insertion of an adenine into the 3,469th, 3,470th, or 3,471st position from the start codon results in a frameshift mutation at codon 1157 with subsequent termination after 3 additional codons.
MeSH terms
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Amino Acid Sequence
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Antigens, Bacterial / genetics*
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Antigens, Bacterial / isolation & purification
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Bacterial Outer Membrane Proteins / genetics*
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Bacterial Outer Membrane Proteins / immunology*
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Bacterial Outer Membrane Proteins / isolation & purification
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Bacterial Proteins*
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Base Sequence
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Blotting, Western
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Cell Wall / genetics
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Cell Wall / physiology
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Cloning, Molecular
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Frameshift Mutation*
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Membrane Glycoproteins*
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Molecular Sequence Data
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Plasmids
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Streptococcus mutans / chemistry
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Streptococcus mutans / genetics*
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Streptococcus mutans / immunology*
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Transformation, Bacterial
Substances
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Antigens, Bacterial
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Bacterial Outer Membrane Proteins
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Bacterial Proteins
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Membrane Glycoproteins
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S-layer proteins