Prognostic value of contrast enhanced Gd-DTPA MRI for development of bone erosive changes in rheumatoid arthritis

Br J Rheumatol. 1996 Dec;35 Suppl 3:26-30. doi: 10.1093/rheumatology/35.suppl_3.26.


Conventional radiograms have been used to quantitate the progression of rheumatoid arthritis, mainly through the assessment of bone erosions, but this approach has many limitations. It has been suggested that an advantage of contrast-enhanced Gd-DTPA MRI over radiography may be its prognostic value due to its ability to show the natural history of active destructive to inactive fibrous pannus. The aim of this study was to evaluate the possible prognostic value of MRI for future development of bone erosive changes in small hand joints in patients with RA. The results of the study confirm that in joints in which inflammatory active pannus is shown by contrast-enhanced MRI, progression of bone-destructive changes can be expected.

Publication types

  • Clinical Trial

MeSH terms

  • Arthritis, Rheumatoid / physiopathology*
  • Bone Resorption / physiopathology*
  • Contrast Media
  • Double-Blind Method
  • Female
  • Gadolinium
  • Gadolinium DTPA
  • Hand / diagnostic imaging
  • Hand / pathology
  • Humans
  • Magnetic Resonance Imaging / methods*
  • Middle Aged
  • Organometallic Compounds*
  • Pentetic Acid / analogs & derivatives*
  • Prognosis
  • Prospective Studies
  • Radiography
  • Wrist / diagnostic imaging
  • Wrist / pathology


  • Contrast Media
  • Organometallic Compounds
  • Pentetic Acid
  • Gadolinium
  • Gadolinium DTPA