Multiple neoplasms following craniospinal irradiation for medulloblastoma in a patient with nevoid basal cell carcinoma syndrome. Case report

J Neurosurg. 1997 Feb;86(2):286-8. doi: 10.3171/jns.1997.86.2.0286.


A 28-year-old man presented to the authors' hospital with multiple intracranial tumors. At 2 years of age, he had undergone resection of a medulloblastoma and received adjunctive craniospinal irradiation. Subsequently, he was diagnosed with nevoid basal cell carcinoma syndrome, Gorlin's syndrome. Since his first presentation, he has required surgery for multiple basal cell carcinomas, an osteochondroma of the rib, two meningiomas, a trigeminal schwannoma, and a pleomorphic liposarcoma, all of which arose within the radiation field. Despite this impressive list of benign and malignant neoplasms, the patient is relatively well and leads a normal life. The authors examine the relationships between Gorlin's syndrome and radiation therapy and the subsequent development of tumors.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Basal Cell Nevus Syndrome / diagnosis
  • Basal Cell Nevus Syndrome / etiology*
  • Basal Cell Nevus Syndrome / surgery
  • Bone Neoplasms / surgery
  • Brain Neoplasms / etiology*
  • Brain Neoplasms / surgery
  • Cerebellar Neoplasms / radiotherapy*
  • Cerebellar Neoplasms / surgery
  • Humans
  • Liposarcoma / surgery
  • Male
  • Medulloblastoma / radiotherapy*
  • Medulloblastoma / surgery
  • Neoplasms, Radiation-Induced* / surgery
  • Ribs