Depletion of CD4+ or CD8+ T-cells prevents Plasmodium berghei induced cerebral malaria in end-stage disease

Parasitology. 1997 Jan;114 ( Pt 1):7-12. doi: 10.1017/s0031182096008293.

Abstract

The role of T-cells in development of experimental cerebral malaria was analysed in C57B1/6J and C57B1/10 mice infected with Plasmodium berghei K173 or Plasmodium berghei ANKA by treatment with anti-CD4 or anti-CD8 mAbs. Mice were protected against cerebral malaria (CM) when anti-CD4 or anti-CD8 mAbs were injected before or during infection. Even in mice in end-stage disease, i.e. with a body temperature below 35.5 degrees C, treatment with anti-CD4 or anti-CD8 antibodies or the combination protected against CM, whereas chloroquine treatment was completely ineffective in inhibiting further development of the cerebral syndrome.

MeSH terms

  • Animals
  • Antibodies, Monoclonal / immunology*
  • Antibodies, Monoclonal / therapeutic use
  • CD4-Positive T-Lymphocytes / immunology*
  • CD8-Positive T-Lymphocytes / immunology*
  • Disease Models, Animal
  • Malaria, Cerebral / immunology*
  • Malaria, Cerebral / prevention & control
  • Mice
  • Mice, Inbred C57BL
  • Parasitemia / immunology
  • Parasitemia / prevention & control
  • Plasmodium berghei / immunology*
  • Specific Pathogen-Free Organisms
  • Thymectomy

Substances

  • Antibodies, Monoclonal