Mesalamine-induced hypersensitivity pneumonitis. A case report and review of the literature

J Clin Gastroenterol. 1997 Jan;24(1):34-6. doi: 10.1097/00004836-199701000-00007.


A 49-year-old man with Crohn's disease treated with prednisone and mesalamine (5-ASA) developed worsening respiratory distress and fever. Symptoms improved after discontinuation of mesalamine. A rechallenge 3 months later caused similar pulmonary symptoms, confirming the association between the drug and the respiratory system. Mesalamine may cause hypersensitivity pneumonitis in patients with Crohn's disease.

Publication types

  • Case Reports

MeSH terms

  • Alveolitis, Extrinsic Allergic / chemically induced*
  • Alveolitis, Extrinsic Allergic / diagnosis
  • Aminosalicylic Acids / adverse effects*
  • Anti-Inflammatory Agents, Non-Steroidal / adverse effects*
  • Drug Hypersensitivity / diagnosis
  • Drug Hypersensitivity / etiology*
  • Humans
  • Inflammatory Bowel Diseases / drug therapy
  • Male
  • Mesalamine
  • Middle Aged


  • Aminosalicylic Acids
  • Anti-Inflammatory Agents, Non-Steroidal
  • Mesalamine