Cell anchorage and the cytoskeleton as partners in growth factor dependent cell cycle progression

Curr Opin Cell Biol. 1997 Feb;9(1):93-8. doi: 10.1016/s0955-0674(97)80157-3.


Several studies in the past year have shown that the cell cycle events typically attributed to a response to growth factors actually require signals provided by both growth factors and the extracellular matrix. Moreover, at least some of these matrix-based effects seem to involve matrix-dependent organization of the cytoskeleton rather than cell adhesion per se. Overall, these studies are providing new insights into the long-appreciated concepts of anchorage- and shape-dependent growth.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Cell Adhesion / physiology*
  • Cell Cycle / physiology*
  • Cytoskeleton / physiology*
  • Growth Substances / physiology*


  • Growth Substances