Actin dynamics in vivo

Curr Opin Cell Biol. 1997 Feb;9(1):54-61. doi: 10.1016/s0955-0674(97)80152-4.

Abstract

Actin dynamics in lamellipodia are driven by continuous cycles of actin polymerization, retrograde flow, and depolymerization. In the past year, advances have been made in identifying signaling pathways that regulate actin-filament uncapping and polymerization, in determining the role of myosin motor proteins in retrograde flow, and in evaluating the role of severing proteins in actin depolymerization. Both Listeria monocytogenes and Saccharomyces cerevisiae have emerged as powerful model organisms for studying actin dynamics in cells.

Publication types

  • Review

MeSH terms

  • Actins / chemistry
  • Actins / physiology*
  • Bacterial Proteins / chemistry
  • Bacterial Proteins / physiology*
  • Fungal Proteins / chemistry
  • Fungal Proteins / physiology*

Substances

  • Actins
  • Bacterial Proteins
  • Fungal Proteins