ERM (ezrin/radixin/moesin) family: from cytoskeleton to signal transduction

Curr Opin Cell Biol. 1997 Feb;9(1):70-5. doi: 10.1016/s0955-0674(97)80154-8.


The ERM family consists of three closely related proteins, ezrin, radixin, and moesin, that are thought to work as cross-linkers between plasma membranes and actin-based cytoskeletons. Recent analyses of the structure and functions of ERM proteins have revealed that these molecules are involved not only in cytoskeletal organization but also in signal transduction. Furthermore, identification of the neurofibromatosis type 2 tumour suppressor, which shows striking sequence similarity to ERM proteins, has increased interest in this family.

Publication types

  • Review

MeSH terms

  • Animals
  • Blood Proteins / physiology*
  • Cytoskeletal Proteins*
  • Cytoskeleton / physiology*
  • Humans
  • Membrane Proteins / physiology*
  • Microfilament Proteins*
  • Phosphoproteins / physiology*
  • Proteins / physiology*
  • Signal Transduction / physiology*


  • Blood Proteins
  • Cytoskeletal Proteins
  • Membrane Proteins
  • Microfilament Proteins
  • Phosphoproteins
  • Proteins
  • ezrin
  • moesin
  • radixin