Automated modelling of the transmembrane region of G-protein coupled receptor by Swiss-model

Recept Channels. 1996;4(3):161-4.


Molecular modelling of the transmembrane helices of G-protein coupled receptors is an increasingly used method to identify the possible three-dimensional environment of key residues. Thereby site-directed mutagenesis experiments, aimed at the understanding of the receptor-ligand interactions, can be designed in a rational way. The modelling methods are however not generally available to experimentalists, and often require expensive software and hardware. To overcome these limitations, we have constructed a World Wide Web server for the automated protein modelling of user-defined transmembrane helices. The service is freely available at this address: http:/(/) +html.

Publication types

  • Review

MeSH terms

  • Animals
  • Computer Communication Networks
  • Computer Simulation*
  • Databases, Factual*
  • GTP-Binding Proteins / chemistry*
  • Humans
  • Models, Molecular*
  • Protein Structure, Secondary
  • Receptors, Cell Surface / chemistry*


  • Receptors, Cell Surface
  • GTP-Binding Proteins