Replicating viruses as selective cancer therapeutics

Mol Med Today. 1996 Dec;2(12):519-27. doi: 10.1016/s1357-4310(97)81456-6.


Replication-competent viruses are used as selective cancer therapeutics and the mechanisms leading to tumor-specific replication and antitumoral efficacy are now becoming apparent. The specific viruses in development include tumor-targeting herpes simplex viruses, autonomous parvoviruses, Newcastle disease viruses and adenovirus. Information is also available on antiviral immunology and viral defenses against host-mediated immunity. This approach has many potential attributes, in addition to potential hurdles that must be overcome.

Publication types

  • Review

MeSH terms

  • Adenoviruses, Human / immunology
  • Adenoviruses, Human / physiology
  • Animals
  • Genetic Vectors / immunology
  • Humans
  • Neoplasms / therapy*
  • Newcastle disease virus / immunology
  • Newcastle disease virus / physiology
  • Parvovirus / immunology
  • Parvovirus / physiology
  • Simplexvirus / immunology
  • Simplexvirus / physiology
  • Viral Proteins / immunology
  • Virus Physiological Phenomena*
  • Virus Replication*


  • Viral Proteins