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, 154 (2), 263-5

Major Depression Following Smoking Cessation


Major Depression Following Smoking Cessation

L S Covey et al. Am J Psychiatry.


Objective: The authors examined the incidence and predictors of major depression following successful smoking cessation treatment, with special attention to the influence of past major depression.

Method: Three-month follow-up data were obtained from 126 subjects who successfully completed a 10-week smoking cessation program.

Results: The 3-month incidence of new major depression following treatment for nicotine dependence was 2%, 17%, and 30% among subjects with histories of no major depression, single major depression, and recurrent major depression, respectively. A history of major depression and persistent withdrawal symptoms independently predicted posttreatment major depression.

Conclusions: Continued patient care beyond the 2-4-week period associated with the nicotine withdrawal syndrome is indicated when abstinence is attempted by smokers with prior major depression.

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