Major depression following smoking cessation

Am J Psychiatry. 1997 Feb;154(2):263-5. doi: 10.1176/ajp.154.2.263.


Objective: The authors examined the incidence and predictors of major depression following successful smoking cessation treatment, with special attention to the influence of past major depression.

Method: Three-month follow-up data were obtained from 126 subjects who successfully completed a 10-week smoking cessation program.

Results: The 3-month incidence of new major depression following treatment for nicotine dependence was 2%, 17%, and 30% among subjects with histories of no major depression, single major depression, and recurrent major depression, respectively. A history of major depression and persistent withdrawal symptoms independently predicted posttreatment major depression.

Conclusions: Continued patient care beyond the 2-4-week period associated with the nicotine withdrawal syndrome is indicated when abstinence is attempted by smokers with prior major depression.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Depressive Disorder / diagnosis
  • Depressive Disorder / epidemiology
  • Depressive Disorder / etiology*
  • Female
  • Follow-Up Studies
  • Humans
  • Incidence
  • Male
  • Middle Aged
  • Nicotine / adverse effects
  • Odds Ratio
  • Personality Inventory
  • Recurrence
  • Smoking Cessation*
  • Substance Withdrawal Syndrome / epidemiology
  • Substance Withdrawal Syndrome / etiology*
  • Tobacco Use Disorder / rehabilitation


  • Nicotine