A structural model for 30 Rh D epitopes based on serological and DNA sequence data from partial D phenotypes

Transfus Clin Biol. 1996;3(6):391-6. doi: 10.1016/s1246-7820(96)80051-6.

Abstract

Both cDNA RHD sequences and reactivity with monoclonal anti-D have been reported in a number of partial D phenotypes, where parts (some epitopes) of the normal D antigen are missing, and anti-D of restricted specificity may be made in response to challenge with normal D positive blood. This paper analyses these reports together and proposes a model for the structure which comprise the epitopes of the Rh D antigen. Some epitopes are proposed to be comprised of continuous peptide sequence within one extracellular loop, whereas others require interactions between two or the extracellular peptide loops.

MeSH terms

  • DNA
  • Epitopes
  • Humans
  • Models, Molecular
  • Phenotype
  • Protein Structure, Tertiary*
  • Rh-Hr Blood-Group System / genetics*
  • Rh-Hr Blood-Group System / immunology
  • Serology

Substances

  • Epitopes
  • Rh-Hr Blood-Group System
  • DNA