Phenobarbital-induced brain growth retardation in artificially reared rat pups

Biol Neonate. 1977;32(1-2):77-82. doi: 10.1159/000240998.


Phenobarbital was administered daily to rat pups during the period of their brain growth spurt. A new technique for artificially rearing rat pups, using chronic intragastric feeding cannulas, was used to prevent drug-induced undernutrition. Rats, receiving neonatal phenobarbital, experienced a marked interruption of early brain growth, although their body weights reflected normal growth.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Animals, Newborn
  • Body Weight / drug effects
  • Brain / drug effects
  • Brain / growth & development*
  • Male
  • Organ Size / drug effects
  • Phenobarbital / administration & dosage
  • Phenobarbital / pharmacology*
  • Rats


  • Phenobarbital