Abstract
A lymphocyte population that expresses surface markers found on T cells and natural killer (NK) cells secretes large amounts of interleukin-4 (IL-4) immediately after T cell receptor ligation. These NK-like T cells are thus thought to be important for the initiation of type 2 T helper cell (TH2) responses. CD1-deficient mice were found to lack this lymphocyte subset, but they could nevertheless mount a protypical TH2 response; after immunization with antibody to immunoglobulin D (IgD), CD1-deficient mice produced IgE. Thus, although dependent on CD1 for their development, IL-4-secreting NK-like T cells are not required for TH2 responses.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Antibodies / immunology
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Antibodies, Anti-Idiotypic / immunology
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Antigens, CD1 / genetics
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Antigens, CD1 / physiology*
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CD3 Complex / immunology
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Cells, Cultured
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Gene Targeting
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Immunoglobulin D / immunology
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Immunoglobulin E / biosynthesis*
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Immunophenotyping
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Interferon-gamma / genetics
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Interferon-gamma / metabolism
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Interleukin-4 / biosynthesis
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Interleukin-4 / genetics
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Interleukin-4 / metabolism*
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Killer Cells, Natural / immunology
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Mice
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Mice, Inbred BALB C
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Mice, Inbred C57BL
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RNA, Messenger / genetics
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RNA, Messenger / metabolism
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Receptors, Antigen, T-Cell / immunology
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T-Lymphocyte Subsets / immunology*
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Th2 Cells / immunology
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beta 2-Microglobulin / genetics
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beta 2-Microglobulin / physiology
Substances
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Antibodies
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Antibodies, Anti-Idiotypic
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Antigens, CD1
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CD3 Complex
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Immunoglobulin D
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RNA, Messenger
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Receptors, Antigen, T-Cell
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beta 2-Microglobulin
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Interleukin-4
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Immunoglobulin E
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Interferon-gamma