RB Kinases and RB-binding Proteins: New Points of View

Trends Biochem Sci. 1997 Jan;22(1):14-7. doi: 10.1016/s0968-0004(96)10070-0.

Abstract

The retinoblastoma protein (RB) binds to a variety of cellular proteins and suppresses cellular growth. Such interactions are regulated by phosphorylation during the cell cycle by several cyclin-dependent kinases, known as RB kinases. Clues to the specific physiological roles of different RB kinases have been obtained. Moreover, interesting functions of the RB protein, other than control of E2F activity, have been found.

Publication types

  • Review

MeSH terms

  • Carrier Proteins / metabolism*
  • Cyclin-Dependent Kinases / metabolism*
  • Humans
  • Retinoblastoma Protein / metabolism*
  • Transcription, Genetic

Substances

  • Carrier Proteins
  • Retinoblastoma Protein
  • Cyclin-Dependent Kinases