Restless legs syndrome and paroxetine

Acta Psychiatr Scand. 1996 Dec;94(6):482-4. doi: 10.1111/j.1600-0447.1996.tb09896.x.


Restless legs syndrome is a frequent dyssomnia with well-known clinical features but uncertain origin and treatment. This paper describes a case of restless legs syndrome worsened by paroxetine. A possible pathogenic hypothesis related to the attributed neurochemical properties of the drug is proposed.

Publication types

  • Case Reports

MeSH terms

  • Adjustment Disorders / drug therapy*
  • Adjustment Disorders / psychology
  • Adult
  • Antidepressive Agents, Second-Generation / adverse effects*
  • Antidepressive Agents, Second-Generation / therapeutic use
  • Humans
  • Male
  • Neurologic Examination / drug effects
  • Paroxetine / adverse effects*
  • Paroxetine / therapeutic use
  • Recurrence
  • Restless Legs Syndrome / chemically induced*


  • Antidepressive Agents, Second-Generation
  • Paroxetine