A 3D- and 4D-ESR imaging system for small animals

Appl Radiat Isot. Nov-Dec 1996;47(11-12):1605-9. doi: 10.1016/s0969-8043(96)00167-4.

Abstract

A new version of in vivo ESR-CT system composed of custom-made 0.7 GHz ESR spectrometer, air-core magnet with a field-scanning coil, three field-gradient coils, and two computers enables up- and down-field, and rapid magnetic-field scanning linearly controlled by computer. 3D-pictures of distribution of nitroxide radicals injected in brains and livers of rats and mice were obtained in 1.5 min with resolution of 1 mm. We have also succeeded in obtaining spatial-time imagings of the animals.

MeSH terms

  • Animals
  • Brain / anatomy & histology
  • Brain / metabolism
  • Cyclic N-Oxides
  • Electron Spin Resonance Spectroscopy / instrumentation
  • Electron Spin Resonance Spectroscopy / methods*
  • Free Radicals / analysis
  • Free Radicals / pharmacokinetics
  • Liver / anatomy & histology
  • Liver / metabolism
  • Male
  • Mice
  • Nitrogen Oxides / analysis
  • Nitrogen Oxides / pharmacokinetics
  • Rats
  • Rats, Wistar
  • Spin Labels
  • Tomography / instrumentation
  • Tomography / methods*

Substances

  • Cyclic N-Oxides
  • Free Radicals
  • Nitrogen Oxides
  • Spin Labels
  • nitroxyl
  • tempol