Leptin and OB-R: body weight regulation by a cytokine receptor

Cytokine Growth Factor Rev. 1996 Dec;7(4):303-9. doi: 10.1016/s1359-6101(96)00040-8.


There has been intense recent interest in the molecules and pathways governing mammalian body weight regulation. Leptin (OB), an ancestral member of the cytokine family, is an adipocyte-secreted circulating hormone exhibiting weight regulatory properties. Recently, the leptin receptor (OB-R) was identified and shown to exhibit sequence homology and functional similarity to members of the class I cytokine receptor family. The mechanisms governing OB-R triggering and signal transduction have begun to be elucidated, providing new insight into the pathways controlling mammalian body weight homeostasis.

Publication types

  • Review

MeSH terms

  • Adipose Tissue / physiology
  • Animals
  • Body Weight*
  • Carrier Proteins / physiology*
  • Cloning, Molecular
  • Hypothalamus / physiology
  • Leptin
  • Mice
  • Mice, Mutant Strains
  • Mice, Obese / physiology
  • Parabiosis
  • Proteins / physiology*
  • Receptors, Cell Surface*
  • Receptors, Leptin
  • Signal Transduction


  • Carrier Proteins
  • Leptin
  • Proteins
  • Receptors, Cell Surface
  • Receptors, Leptin
  • leptin receptor, mouse