Severe humoral hypercalcemia in primary isolated non-Hodgkin's lymphoma of the heart

Med Pediatr Oncol. 1997 Mar;28(3):183-6. doi: 10.1002/(sici)1096-911x(199703)28:3<183::aid-mpo5>3.0.co;2-f.

Abstract

The etiology of hypercalcemia was investigated in a patient with primary isolated non-Hodgkin's lymphoma of the heart. There was no evidence of bone involvement, and parathyroid hormone and calciterol levels were suppressed. Plasma parathyroid-hormone-related protein (PTHrP 1-86) detected by immunoradiometric assay was increased (15 pmol/l compared with < 0.3 pmol/l in a control). We demonstrated that PTHrP was the humoral mediator of severe hypercalcemia in our patient.

Publication types

  • Case Reports

MeSH terms

  • Heart Neoplasms / complications*
  • Heart Neoplasms / diagnosis
  • Humans
  • Hypercalcemia / blood
  • Hypercalcemia / etiology*
  • Immunoradiometric Assay
  • Lymphoma, Non-Hodgkin / complications*
  • Lymphoma, Non-Hodgkin / diagnosis
  • Male
  • Middle Aged
  • Parathyroid Hormone / blood
  • Parathyroid Hormone-Related Protein*
  • Peptide Fragments / blood
  • Peptides / blood

Substances

  • Parathyroid Hormone
  • Parathyroid Hormone-Related Protein
  • Peptide Fragments
  • Peptides
  • parathyroid hormone-related protein (1-86)